Chronic Telogen Effluvium (CTE) is a nonscarring, generalized form of hair loss triggered by an uncertain cause. This type of excessive shedding affects the whole scalp and is common in otherwise healthy middle-aged women. 

Chronic Telogen Effluvium causes diffuse thinning of scalp hair, along with the temporary recession of the hairline. CTE is considered a distinct, separate, entity from acute telogen effluvium due to its fluctuating, long course that can last 5 to 7 years. 

What happens during Chronic Telogen Effluvium?

Chronic Telogen EffluviumHuman hair follows a four stage growth cycle:

  • the anagen phase (growth phase),
  • the catagen phase (transition phase),
  • the telogen phase (resting phase),
  • and the exogen phase (shedding phase).

In Telogen effluvium, the early entry of hair follicles in the telogen phase is one of the established pathophysiologies. This entry transition increases the rate of daily hair loss to more than the regular 100 strands per day. However, as the hair loss involves the entire scalp, the suffering individual observes a thinning of the hair rather than the development of full-blown baldness.

Functional variants of CTE.

Five potential alterations in the hair cycle are reported to be present in chronic telogen effluvium. Each of these alterations favors certain predisposed conditions that are either potential risks, or stimulating factors for Telogen Effluvium development.

  • Immediate anagen release is observed when hair follicles abruptly switch from anagen to telogen phase prematurely. The result of this alteration is visible within 2-3 months.
  • Short anagen syndrome is the most common type of telogen effluvium with an idiopathic cause.
  • Immediate telogen release generally occurs with drug-induced shortening of telogen resulting in premature hair loss. Drugs such as minoxidil can precipitate immediate telogen release.
  • Delayed telogen release, this variant of TE is frequently responsible for seasonal hair loss, involving a prolonged telogen phase followed by a delayed transition to anagen.

What are some suspected causes of chronic telogen effluvium?

CTE can also be classified into primary or secondary types, with the Primary CTE remaining idiopathic, and Secondary due to any underlying conditions. Some of the common suspected secondary causes of Chronic Telogen Effluvium involving the whole scalp include:

  • acute telogen effluvium,
  • anagen effluvium,
  • drugs,
  • hypothyroidism,
  • iron deficiency,
  • and nutritional disturbances.

Furthermore, emotional or physiological stress are also common trigger factors. These are generally noted after stressful events such as childbirth, chronic illness, major surgery, and severe emotional disorders.

How is it diagnosed?

The diagnosis for CTE is made by excluding other conditions that cause chronic hair loss. History and complete physical examination further support the diagnosis. The routine investigation carried out includes full blood count and thyroid function tests. If the clinical indication arises, syphilis serology, antinuclear antibody (ANA) titer, serum zinc levels, and other investigations may also be performed.

How is it managed?

The first step in the management of CTE remains patient counseling as the conditions is believed to be self-limiting. Removing the triggering factor(s) is the next step to ensure rapid recovery, this can be done through:

  • removal of physical and psychological stresses,
  • avoidance of catagen inducing drugs (beta-blockers, retinoids, anticoagulants, or antithyroid drugs),
  • and treatment of conditions that induce early telogen (thyroid dysfunction, hyperandrogenism, or hyperprolactinemia).

Currently, no FDA approved drug is highly efficient as catagen inhibitors or anagen inducers. Supplementation therapy for deficiencies that promote catagen, such as iron, zinc, estradiol, and proteins, is also recommended by multiple studies. 

Minoxidil is the only recommended medication that is employed in patients with CTE and has shown to prolong the anagen phase.

 

 

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